La niebla mental provocada por el COVID

Un estudio publicado en BioRxiv sugiere que incluso las infecciones leves por coronavirus pueden provocar síntomas neurológicos a largo plazo asociados con un COVID prolongado.

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Científicos dirigidos por la neuróloga de la Universidad de Stanford, Michelle Monje, reconocieron deterioro cognitivo y dificultades con la atención y la memoria, síntomas conocidos como “niebla mental”.

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La preimpresión mostró que la vía de la neuroinflamación se puede activar incluso sin que el coronavirus infecte una sola célula cerebral.

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Los investigadores estudiaron muestras de nueve cerebros humanos de personas que murieron en marzo de 2020 y luego se confirmó que tenían COVID-19.

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Sus cerebros mostraron los mismos patrones de actividad de microglía que surgieron en ratones infectados y en estudios de deterioro cognitivo relacionado con la quimioterapia (CRCI) en humanos.

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El estudio insinúa la posibilidad de intervenciones terapéuticas para tratar o prevenir los síntomas neurológicos de la afección. “Algunos tratamientos de CRCI ya se están explorando”, dijo Monje.

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“La configuración experimental no pudo explicar los efectos de las vacunas, las infecciones previas u otros factores de confusión”, dijo la directora de la investigación.

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Este estudio sienta las bases para futuros experimentos al tiempo que sugiere la posibilidad de intervenciones clínicas para la niebla cerebral relacionada con el coronavirus.

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“Debido a que la vía inflamatoria causada por los casos leves de COVID no parece matar las neuronas irremplazables, lo que estamos describiendo aquí, es todo potencialmente reversible”, concluyó.

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